28 October 2026

Neoadjuvant treatment

This page covers how to assess readiness, educate patients on the “why now” of neoadjuvant treatment, and monitor early toxicities and red flags between visits. You will also find tumour-specific nuances, living well supports, population considerations, and practical recommendations to guide consistent care.

KEY NURSING CONSIDERATIONS

 Consider the need for assessment, information provision, support or management on the following topics:  

Bladder health Educate the patient on maintaining adequate hydration and strong core muscles through regular pelvic floor muscle exercises. Assess bladder function prior to treatment and provide patient education on treatment-specific bladder health considerations. Facilitate referral to specialist continence and/or pelvic floor services where indicated. Optimal bladder health supports effective urinary function, reduces the risk of urinary tract infection, and may help minimise treatment-related urinary complications.

Bowel health Educate the patient on maintaining adequate hydration, sufficient fibre intake, and a healthy diet to prevent constipation or diarrhoea. Assess bowel health prior to treatment and provide education on treatment-specific bowel health considerations. Facilitate referral to specialist continence and/or pelvic floor services where indicated. Maintaining bowel health and a healthy gut microbiome supports immune function and may help reduce the impact of treatment-related toxicities.

Clinical trials Educate and support the patient who is considering, or is enrolled in, cancer clinical trials. Clinical trials are research studies involving human volunteers to evaluate the safety and effectiveness of new treatments, medicines, vaccines, or medical devices and may include pharmaceutical and non-pharmaceutical (such as lifestyle) interventions.

Cultural considerations Assess and address cultural considerations to ensure the provision of culturally safe care. Cultural considerations encompass diverse beliefs, communication styles, family structures and decision-making processes, perceptions of illness, language needs, use of traditional medicines, and gender roles and preferences.

Cytotoxic precautions Educate the patient and carers about cytotoxic precautions, and ensure that nurses follow these cytotoxic precautions themselves as required. Cytotoxic precautions are safety measures to prevent exposure to hazardous anti-cancer therapies.

Dental and oral health Educate the patient about the importance of dental and oral health whilst undergoing cancer treatment. Dental and oral health is care of the mouth, gums and teeth, and is crucial to prevent severe infections, manage painful side effects, and maintain nutrition, as cancer treatments can weaken the immune system and damage oral tissues, often resulting in treatment delays.

Diagnosis understanding Assess the patient's and carer's understanding of the diagnosis including disease type, location, stage/grade and test results. Comprehensive understanding improves patient outcomes, facilitates shared decision-making, reduces anxiety, improves treatment adherence and overall quality of life.

Dietary considerations Assess appetite and dietary intake with a validated tool and provide dietary advice, or refer as required to a dietitian to support the patient to maintain a healthy diet. The side effects of cancer treatment, or the effects of the cancer itself can make it difficult for the patient to meet their nutritional needs. Choosing nourishing foods that are high in protein and energy can help support adequate intake during this time.

Exercise and physical activity Assess the patient's current physical activity and engagement in exercise, educate about the benefits, and refer as necessary to physiotherapy or exercise physiology. Exercise is a safe and effective therapy for people with cancer and reduces cancer-related fatigue, eases treatment side effects, boosts mood and mental wellbeing, and improves physical function, bone density, and sleep quality.

Family and caregiver support Assess the supportive care needs of family and caregivers. Utilise valid and reliable tools to assess caregiver distress and supportive care needs and make referrals where possible. Informal caregiving for someone with cancer can cause physical, emotional and financial distress for caregivers that can compromise both their health and the patient's care.

Family history Discuss and document the patient's family health history and assess genetic risk. Family history is a crucial tool for assessing cancer risk, as some cancers can be caused by inherited genetic mutations, and a detailed history can determine if genetic testing is required.

Finance and employment Assess the impact of cancer on the patient's financial and employment situation using a validated tool, and facilitate referral as required to support services, including social work. Cancer and its treatment can be a financial strain, caused by extra costs during and after treatment, or loss of income, and some people may be discriminated against at work due to their cancer diagnosis.

Functional status Assess the patient's functional status using a validated tool such as the Eastern Cooperative Oncology Group (ECOG) scale. ECOG is a 0–5 scale used by clinicians to assess the functional ability of a person with cancer, and to guide appropriate treatment decisions.

Genetic testing and counselling Educate the patient regarding genetic testing and provide support to discuss risks, and consider the benefits and limitations. Genetic testing (or germline testing) for cancer assesses inherited gene mutations that increase cancer risk and guide treatment decisions for some gynaecological cancers.

Goals of care Support the patient and carers to ensure that goals of care are person-centred and facilitate shared decision making that aligns medical treatment with a person's values, priorities, and quality of life. Goals of care in cancer align with a person's values, may focus on curing the disease, prolonging life or maximising quality of life, and can be dynamic throughout the patient's cancer journey.

Health literacy Assess the patient's health literacy levels and adapt education and information provision to meet their needs and preferences. Health literacy is the ability to access, understand and apply health information to make informed decisions and manage health.

Lymphoedema screening, education & management Provide the patient early education on lymphoedema, facilitate lymphoedema screening and make appropriate referrals to lymphoedema specialists. Lymphoedema is a condition resulting in chronic swelling caused by damage to the lymphatic system, which may result from cancer and/or its treatment.

Molecular profiling Educate and support the patient regarding molecular profiling. Molecular profiling is a method used to identify specific tumour biomarkers to determine whether targeted treatments are available.

Multidisciplinary team (MDT) meeting & involvement Actively contribute and advocate for the patient within MDT meetings and throughout the care trajectory. Nurses are vital members of the MDT, acting as patient advocates, and providing holistic, person-centred insights to better coordinate clinical decisions and patient care.

Navigation support Support the patient to navigate through and across services ensuring they have a key point of contact at all times across the care trajectory. Navigation improves patient outcomes by providing education, emotional support, and logistical assistance, ensuring timely, high-quality, and person-centred care.

Points of contact Provide the patient and carers with contact details for their key point of contact at your health service and who they should contact out of hours. The nurse often acts as the primary point of contact, supporting the patient and providing communication between the patient, the primary health care provider and the treating team.

Psychological and emotional support Assess the psychological and emotional support needs of the patient and carers using validated tools and provide support and referrals to services as required. Understanding the psychological and emotional support needs can help ensure access to appropriate services, which can improve survival outcomes, enhance treatment adherence, and reduce the risk of long-term mental health issues.

Quality of life Enhance the patient's Quality of Life (QoL) by addressing their physical, emotional, and social needs through a holistic, individualised approach to care. QoL is a multidimensional, subjective perspective of a patient's overall wellbeing – including physical, emotional, social and functional needs across their disease trajectory – and is a key goal of all cancer care.

Sexual health Assess and discuss the impact of gynaecological cancers on the patient's sexual health, use validated screening tools to assess sexual function and refer to specialist services as required. Gynaecological cancers significantly affect sexual health, including physical and hormonal changes, psychological responses, fertility and contraception and effects on relationships and intimacy.

Side-effect management Assess for and manage side-effects of treatment in conjunction with the multidisciplinary team using validated tools where indicated. Effective management of cancer treatment side effects is crucial to maintain treatment adherence, prevent complications, and improve quality of life.

Social supports Assess the patient's current family and social supports and the need for referral for additional support. Family and social support can improve quality of life by providing essential resources to cope with stress, help manage treatment side effects, and reduce emotional distress.

Symptom management Assess for and educate the patient on the symptoms of their disease and manage these in conjunction with the multidisciplinary team. The management of symptoms will be dependent on the goals of care (curative or palliative intent) but must always give consideration to the patient's quality of life, function, distress, and tolerance of treatments.

Transport and accommodation Assess the patient's transport and accommodation needs and facilitate access to available assistance. Transport and accommodation management through government-funded Patient Assisted Travel Schemes (PATS) is important, particularly for regional and rural patients, as it can directly impact access to treatment, lower financial burden, and reduce stress.

Treatment adherence/compliance Assess the patient for adherence to treatment and seek to understand and address any barriers to engagement in optimal care. Treatment adherence is critical to achieve optimal prognosis and improved outcomes, whilst non-adherence can lead to disease progression and increased mortality.

Treatment induced menopause Discuss and educate the patient for expected treatment-induced menopause and facilitate management of symptoms. Consider referral to specialised menopause after cancer services if available. Treatment-induced menopause is the sudden cessation of ovarian function due to surgical or cancer treatments.

Treatment plan Ensure the patient understands their treatment plan including the timing, duration and expected recovery from each treatment modality. A treatment plan outlines how a patient's cancer will be treated over time.

Venous access Assess the patient's venous access requirements, giving consideration to therapy needs (vesicant potential, duration), with patient factors, such as vein quality, lifestyle, and comorbidities, and discuss and facilitate central venous access device insertion if required. Reliable venous access is important to safely deliver long-term, intensive therapies and significantly improve patient comfort and quality of life.

PRACTICE RECOMMENDATIONS

Ensure all people (especially young people and their carers) have an awareness and understanding of Human Papillomavirus (HPV) vaccination, assess vaccination status and recommend HPV vaccination

When? For all 12-13 year old people, ideally prior to any sexual activity, in addition to other people at any age who have not been previously vaccinated, with particular attention to priority populations at increased risk of HPV-related disease. 

How? Provide clear age-appropriate information by discussing the purpose of HPV vaccination to prevent HPV infections, reducing the risk of cancer. Offer written information to reinforce understanding. Facilitate vaccination access if indicated. 

Evidence 

National Strategy for the Elimination of Cervical Cancer in Australia

Optimal care pathway for women with cervical cancer 

 

Assess cervical screening status of all women and people with a cervix aged from 25 to 74 years and facilitate screening for those not screened within the past 5 years

When? At initial contact and opportunistically thereafter. 

How? Promote and discuss cervical screening options, provide supporting written information and facilitate screening access if indicated. 

Evidence 

National Strategy for the Elimination of Cervical Cancer in Australia

Optimal care pathway for women with cervical cancer 

TUMOUR-SPECIFIC CONSIDERATIONS

Ovarian cancers (including fallopian tube & primary peritoneal cancers)

  • Consider referral for multidisciplinary prehabilitation, if service available
  • Assess for chemotherapy-induced peripheral neuropathy (CIPN)
  • Assess and monitor for ascites
  • Assess and provide information and care on bowel management (i.e. diarrhoea, constipation, monitor for bowel obstruction)
  • Assess for nausea and vomiting and potential risk for malnutrition
  • Assess emotional wellbeing, e.g. fear of recurrence
  • Assess need for a central venous access device (CVAD)
  • Refer to Ovarian Cancer Australia Teal Support Program

Uterine cancers (including endometrial cancer)

  • Chemotherapy may be recommended for palliative symptom control
  • Educate on potential impacts of concurrent chemotherapy and radiotherapy
  • Consider referral for multidisciplinary prehabilitation, if service available

Cervical cancer

  • Neoadjuvant treatment typically not used

Vulval cancer

  • Neoadjuvant treatment typically not used

Vaginal cancer

  • Neoadjuvant treatment typically not used

Gestational trophoblastic disease/neoplasia

  • Neoadjuvant treatment typically not used

LIVING WELL AND DELIVERY CONSIDERATIONS

LIVING WELL
  • Encourage ongoing GP contact for comorbid condition management, immunisation, screening, chronic disease, mental health care plan, and other health concerns
  • Offer health promotion and lifestyle maintenance solutions
  • Facilitate healthy lifestyle modifications
  • Discuss and facilitate advance care planning for patients with a life-limiting illness
  • Survivorship Care Plan
DELIVERY CONSIDERATIONS

Interpreter services (inc Auslan) Facilitate and utilise professional medical interpreter services for all patients who communicate or prefer to communicate in languages other than English. Avoid the use of family members as interpreters and, where possible, pre-brief the interpreter if complex medical language or sensitive conversations are required. Optimal use of interpreter services will enable clear and thorough information exchange between patients and health care professionals, ensuring patients are fully informed and included in decision making about their care.

Hearing status Assess the patient's hearing and adjust care provision for patients with hearing impairment including use of hearing and visual aids, and Auslan interpreter as required. Sign language interpreters are vital to ensure accurate communication, and accessibility for hearing impaired individuals.

Vision status Assess the patient for vision impairment and adjust care provision including use of vision, auditory and mobility aids. Vision impairment is the reduced ability to see that cannot be fully corrected with glasses or contact lenses, and may impact activities of daily living such as reading and driving.

Trauma-informed care Provide trauma-informed care to all people with a gynaecological cancer. Trauma-informed care is a person-centred approach to care that recognises the widespread impact of trauma and actively prevents re-traumatisation through empowering patients and providing physical and emotionally safe care.

Learning style Assess and discuss the patient's preferred learning style and needs for receiving education and information. Common adult learning styles include visual, auditory, and kinaesthetic or a combination of these and information provision should be offered in a way that best meets their needs and preferences.

Health literacy Assess the patient's health literacy levels and adapt education and information provision to meet their needs and preferences. Health literacy is the ability to access, understand and apply health information to make informed decisions and manage health.

Accessibility and support for priority groups Identify and support the individual needs of people with cancer from priority population groups to enable access to optimal cancer care including Aboriginal and Torres Strait Islander people, culturally and linguistically diverse people, LGBTQIA+ people, older and younger people, those living in rural and remote areas, people experiencing mental illness or disability, or those living in low socioeconomic circumstances. These priority population groups are known to experience poorer cancer outcomes and require a person-centred, targeted approach to care to achieve equitable outcomes.

Appointment type (face to face/telehealth) Discuss and facilitate the most appropriate appointment type for the patient with consideration of the need for physical examination, the delivery of sensitive information, access to technology and skills to use, distance the patient needs to travel and availability of transport and the need for interpreters and/or support people. Understanding patients' needs and preferences and balancing this with clinical needs will ensure the best appointment type is selected to meet their needs.

Communication with treatment team & general practitioner (GP) Ensure timely and accurate communication of treatment plan and any changes to care to enable continuity of care between the cancer team and general practitioner. Clearly communicate escalation pathways from primary care back to the treatment team and ensure the patient consents to the sharing of this information. Timely and accurate communication between healthcare settings reduces the burden on patients to communicate their story repeatedly.

More comprehensive care considerations

ABORIGINAL AND TORRES STRAIT ISLANDER PEOPLE

  • Cultural sensitivity regarding Women’s Business
  • Involve and support extended family, kin and community (mob)
  • Ensure culturally safe communication and information (verbal and written)
  • Recognise connection to Country and facilitate care on Country where possible
  • Consider the use of cultural or bush medicine, or traditional healers that may be accessed by the person
  • Seek permission to refer to an Aboriginal or cultural liaison officer, nurse navigator or other support role if available
  • Sensitivity and acknowledgement about Sorry Business

More detail

MORE INFORMATION

For Nurses
Points for MDT discussion
  • Advocate for patient preferences
  • Consider oncofertility needs
  • Consider clinical trials
  • Facilitate genetics referral (germline and somatic) prior to commencing, if appropriate
  • Consider CVAD
  • Consider goals of treatment (cure vs control, palliative)
Resources for nurses

Liaise with GP/cancer nurse/rural cancer nurse.

Assessment tools

 

For Patients
What is next for the patient? Who needs to know?
  • Communicate with patient and/or carer, family re: date to commence neoadjuvant treatment, orientation to treatment centre, patient education for treatment protocol
  • Facilitate appointment with gynaecological oncologist before/during neoadjuvant treatment
  • Discuss timing of restaging scans (CT, MRI, PET, CA125) and timing of follow-up appointment with local treatment centre post-surgery
  • MDT re-discussion after C3 to discuss suitability for interval debulking surgery
  • Communicate with GP
Common referrals
  • Allied health (dietitian, psychology, social work)
  • Exercise physiology
  • Stoma nurse, if applicable
  • Lymphoedema specialist
  • Continence nurse
  • Ovarian Cancer Australia Teal Support Program
  • Rare Cancers Australia
Resources for patients